中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (34): 6317-6320.doi: 10.3969/j.issn. 2095-4344.2012.34. 010

• 纳米生物材料 nanobiomaterials • 上一篇    下一篇

纳米胶原基骨修复牙周病及根尖周病骨缺损

李 睿1，王春兰2，范月静2，连小洁3   

  1. 1天津医科大学口腔医院，天津市 300070；
    2天津医科大学第二医院，天津市 300211；
    3清华大学材料系，北京市 100084
  • 收稿日期:2012-01-29 修回日期:2012-03-19 出版日期:2012-08-19 发布日期:2012-08-19
  • 作者简介:李睿☆，男，1982年生，山东省郓城市人，汉族，2010年日本大学松户齿学部毕业，博士，讲师，主要从事口腔生物材料学研究。 lirui198228@163.com

Application of nano-collagen basal bone in repairing bone defects of periapical and periodontal diseases

Li Rui1, Wang Chun-lan2, Fan Yue-jing2, Lian Xiao-jie3   

  1. 1Department of Prosthodontics, Stomatology Hospital of Tianjin Medical University, Tianjin 300070, China;
    2Department of Stomotology, the Second Hospital of Tianjin Medical University, Tianjin 300211,China;
    3Department of Materials Science and Engineering, Tsinghua University, Beijing 100054, China
  • Received:2012-01-29 Revised:2012-03-19 Online:2012-08-19 Published:2012-08-19
  • About author:Li Rui☆, Doctor, Lecturer, Department of Prosthodontics, Stomatology Hospital of Tianjin Medical University, Tianjin 300070, China lirui198228@163.com

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372

被引次数

2

摘要：

背景：纳米胶原基骨是与天然骨松质结构相似的一种人工合成仿生骨，在促进新骨形成同时可降解吸收。
目的：评价纳米胶原基骨修复牙周骨缺损及根尖周骨缺损的效果。
方法：①选择根尖周骨缺损患者50例，完成根尖搔刮治疗后，其中18例植入纳米胶原基骨(实验组)，14例植入瑞福人工骨(对照组)，18例未植入任何材料(空白对照组)。②选择牙周病骨缺损呈垂直吸收慢性牙周炎患者23例，实验组17例行牙周翻瓣植入纳米胶原基骨，对照组6例牙周翻瓣植入瑞福人工骨。
结果与结论：①根尖周骨缺损：治疗后6个月，实验组与对照组骨性愈合及骨化程度差异无显著性意义，但均明显高于空白对照组(P < 0.01)。②慢性牙周炎：治疗后6个月，实验组与对照组牙周袋深度、附着丧失、牙龈出血指数均较治疗前明显改善(P < 0.05)，但两组之间差异无显著性意义(P > 0.05)，且两组角形吸收或垂直吸收处均有骨高度增加伴新附着形成。表明纳米胶原基骨可加快缺损部位正常骨组织结构的重建，促进骨缺损早期再生修复。

关键词: 纳米胶原基骨, 瑞福人工骨, 根尖周病, 牙周病, 骨缺损, 骨引导

Abstract:

BACKGROUND: Nano-collagen basal bone is a synthetic bionic bone and its structure is similar to natural cancellous bone structure, which can promote new bone formation with biodegradable absorption.
OBJECTIVE: To evaluate the repair effect of nano-collagen basal bone on periodontal and periapical bone defects.
METHODS: ①Totally 50 cases were selected and they were failure of root canal treatment and their periapical bones were destroyed more than 1 cm×1 cm. After scratch in root apex was scraped, 18 cases of them were implanted with nano collagen basal bone (experimental group), and 14 cases were implanted with Relive artificial bone (control group), while 18 cases were given nothing (blank control group). ②Twenty-three cases of bone defects from periodontal disease in vertical absorption were selected. A total of 17 cases underwent periodontal flap surgery and nano-collagen basal bone implantation, while 6 cases underwent periodontal flap surgery and Relive artificial bone implantation.
RESULTS AND CONCLUSION: ①Periapical bone defects: The bony union and calcification extent of the experimental group and control group had no significant difference at month 6 postoperatively, but were both higher than those of the blank control group (P < 0.01). ②Chronic periodontitis: The depth of pocket, adhesion loss and gums bleeding index were improved significantly in the experimental group and control group at month 6 postoperatively (P < 0.05), but there was no significant difference between the two groups (P > 0.05). Moreover, in the regions of angle-shaped and vertical absorption, bone height increase was found with new attachment formed. These findings suggest that nano-collagen basal bone can accelerate the reconstruction of normal structure in bone defects and promote the early regeneration of bone defects.

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